899 research outputs found

    Research Mentoring and Scientist Identity: Insights from Undergraduates and their Mentors

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    Background Mentored research apprenticeships are a common feature of academic outreach programs that aim to promote diversity in science fields. The current study tests for links between three forms of mentoring (instrumental, socioemotional, and negative) and the degree to which undergraduates psychologically identify with science. Participants were 66 undergraduate-mentor dyads who worked together in a research apprenticeship. The undergraduate sample was predominantly composed of women, first-generation college students, and members of ethnic groups that are historically underrepresented in science. Results Findings illustrated that undergraduates who reported receiving more instrumental and socioemotional mentoring were higher in scientist identity. Further, mentors who reported engaging in higher levels of negative mentoring had undergraduates with lower scientist identity. Qualitative data from undergraduates’ mentors provided deeper insight into their motivation to become mentors and how they reason about conflict in their mentoring relationships. Conclusions Discussion highlights theoretical implications and details several methodological recommendations

    Full-genome characterization and genetic evolution of West African isolates of Bagaza virus

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    Bagaza virus is a mosquito-borne flavivirus, first isolated in 1966 in Central African Republic. It has currently been identified in mosquito pools collected in the field in West and Central Africa. Emergence in wild birds in Europe and serological evidence in encephalitis patients in India raise questions on its genetic evolution and the diversity of isolates circulating in Africa. To better understand genetic diversity and evolution of Bagaza virus, we describe the full-genome characterization of 11 West African isolates, sampled from 1988 to 2014. Parameters such as genetic distances, N-glycosylation patterns, recombination events, selective pressures, and its codon adaptation to human genes are assessed. Our study is noteworthy for the observation of N-glycosylation and recombination in Bagaza virus and provides insight into its Indian origin from the 13th century. Interestingly, evidence of Bagaza virus codon adaptation to human house-keeping genes is also observed to be higher than those of other flaviviruses well known in human infections. Genetic variations on genome of West African Bagaza virus could play an important role in generating diversity and may promote Bagaza virus adaptation to other vertebrates and become an important threat in human health

    Radio, Internet et satellite au Sénégal pour lutter contre les feux de brousse

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    En Afrique, certains projets utilisent les technologies de l’information et de la communication (TIC) depuis de nombreuses années de manière spontanée. Que la technologie employée soit nouvelle, analogique, vieille ou traditionnelle, qu’importe. Ce qui compte, c’est l’efficacité par rapport aux objectifs visés, la durabilité et l’autonomie. Là où des ordinateurs performants avaient été installés, les groupements paysans ont vite compris que l’achat d’un modem leur permettait de se mettre en r..

    Radio, Internet und Satellit zur Bekämpfung der Buschfeuer im Senegal

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    In Afrika werden schon seit Jahren Informations- und Kommunikationstechnologien (IKT) in einigen Projekten spontan eingesetzt. Ob es sich um eine neue, eine analoge, eine alte oder eine traditionelle Technologie handelt, ist nicht wichtig. Wichtig ist nur, dass die angestrebten Ziele effizient, nachhaltig und autonom erreicht werden. Dort wo leistungsfähige Computer verfügbar sind, begriffen die Bauernvereinigungen schnell, dass der Kauf eines Modems ihnen hilft, sich mit anderen Vereinigunge..

    Adolescent Civic Involvement and the Great Recession of 2008: Testing the Certainty of Employment

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    This study employs data from the Educational Longitudinal Study of 2002 to investigate the relationship between the voluntary civic involvement of high school students and their subsequent employment status during the Great Recession of 2008. It also examines whether volunteering with a specific type of community organization relates to future employment. Such youth civic involvement offers experiential learning in which students use academic knowledge and skills to address specific community needs. Along the pathways to employment, students achieve learning objectives while experiencing real-world issues. Using SPSS, the authors conduct a logistical regression, and discuss the results using odds ratios. The authors also include gender, ethnicity, family composition, parents’ highest level of education, and family income as demographic variables

    Bank Manager Strategies to Retain Skilled Employees Beyond 5 Years

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    AbstractThe banking industry is fraught with low employee retention threatening the bank’s ability to perform optimally. Bank managers who fail to implement strategies to retain skilled employees experience reduced productivity and increased turnover costs. Grounded in the job embeddedness theory, the purpose of this qualitative single-case was to explore strategies bank managers use to minimize employees\u27 intent to leave during downtimes in the banking industry. The participants were four employees of a Fortune 500 bank located in the U.S. in Virginia. Data were collected using semistructured interviews and a review of organizational employee handbooks. The six themes identified through a thematic analysis were merging of skillsets, reduction of turnover, strategy relevance, continuous training, incentives, and workplace culture. A key recommendation is for bank managers to acknowledge employees\u27 achievements through monthly employee recognition and ongoing training, incentives, and workplace culture. The implications for positive social change include the potential to enhance the quality of life for skilled employees in the bank industry

    Development and validation of sensitive real-time RT-PCR assay for broad detection of rabies virus

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    Rabies virus (RABV) remains one of the most important global zoonotic pathogens. RABV causes rabies, an acute encephalomyelitis associated with a high rate of mortality in humans and animals and affecting different parts of the world, particularly in Asia and Africa. Confirmation of rabies diagnosis relies on laboratory diagnosis, in which molecular techniques such as detection of viral RNA by reverse transcription polymerase chain reaction (RT-PCR) are increasingly being used.  In this study, two real-time quantitative RT-PCR assays were developed for large-spectrum detection of RABV, with a focus on African isolates. The primer and probe sets were targeted highly conserved regions of the nucleoprotein (N) and polymerase (L) genes.  The results indicated the absence of non-specific amplification and cross-reaction with a range of other viruses belonging to the same taxonomic family, i.e Rhabdoviridae, as well as negative brain tissues from various host species. Analytical sensitivity ranged between 100 to 10 standard RNA copies detected per reaction for N-gene and L-gene assays, respectively. Effective detection and high sensitivity of these assays on African isolates showed that they can be successfully applied in general research and used in diagnostic process and epizootic surveillance in Africa using a double-check strategy

    Metagenomic sequencing, molecular characterization, and Bayesian phylogenetics of imported type 2 vaccine-derived poliovirus, Spain, 2021

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    Introduction: In 2021, a type 2 vaccine-derived poliovirus (VDPV2) was isolated from the stool of a patient with acute flaccid paralysis (AFP) admitted to Spain from Senegal. A virological investigation was conducted to characterize and trace the origin of VDPV2. Methods: We used an unbiased metagenomic approach for the whole-genome sequencing of VDPV2 from the stool (pre-treated with chloroform) and from the poliovirus-positive supernatant. Phylogenetic analyses and molecular epidemiological analyses relying on the Bayesian Markov Chain Monte Carlo methodology were used to determine the geographical origin and estimate the date of the initiating dose of the oral poliovirus vaccine for the imported VDPV2. Results: We obtained a high percentage of viral reads per total reads mapped to the poliovirus genome (69.5% for pre-treated stool and 75.8% for isolate) with a great depth of sequencing coverage (5,931 and 11,581, respectively) and complete genome coverage (100%). The two key attenuating mutations in the Sabin 2 strain had reverted (A481G in the 5'UTR and Ile143Thr in VP1). In addition, the genome had a recombinant structure between type-2 poliovirus and an unidentified non-polio enterovirus-C (NPEV-C) strain with a crossover point in the protease-2A genomic region. VP1 phylogenetic analysis revealed that this strain is closely related to VDPV2 strains circulating in Senegal in 2021. According to Bayesian phylogenetics, the most recent common ancestor of the imported VDPV2 could date back 2.6 years (95% HPD: 1.7-3.7) in Senegal. We suggest that all VDPV2s circulating in 2020-21 in Senegal, Guinea, Gambia, and Mauritania have an ancestral origin in Senegal estimated around 2015. All 50 stool samples from healthy case contacts collected in Spain (n = 25) and Senegal (n = 25) and four wastewater samples collected in Spain were poliovirus negative. Discussion: By using a whole-genome sequencing protocol with unbiased metagenomics from the clinical sample and viral isolate with high sequence coverage, efficiency, and throughput, we confirmed the classification of VDPV as a circulating type. The close genomic linkage with strains from Senegal was consistent with their classification as imported. Given the scarce number of complete genome sequences for NPEV-C in public databases, this protocol could help expand poliovirus and NPEV-C sequencing capacity worldwide.This study was partially supported by two grants from the Instituto de Salud Carlos III [grant numbers PI18CIII/00017 and PI20CIII/00005].S

    Dynamic analysis of concrete structural behaviour - Estimation of seismic vulnerability of Andorran Civil Protection building

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    This work is a part of the cross-border area POCRISC project supported by Interreg POCTEFA program. Damage detection and localization is studied on a concrete building located in Andorra using Modal Operational Analysis coupled with numerical modelling by Finite Element
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